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Teenage Mutant Ninja Turtles: Mutant Mayhem is a 2023 American computer-animated superhero film directed by Jeff Rowe, who co-wrote the screenplay with Seth Rogen, Evan Goldberg, Dan Hernandez, and Benji Samit. It is the seventh theatrical Teenage Mutant Ninja Turtles film and a reboot of the Turtles series. The film stars the voices of Micah Abbey, Shamon Brown Jr., Nicolas Cantu, and Brady Noon, alongside an ensemble voice cast that includes Ayo Edebiri, Maya Rudolph, John Cena, Rogen, Rose Byrne, Natasia Demetriou, Giancarlo Esposito, Jackie Chan, Ice Cube, Paul Rudd, Post Malone, and Hannibal Buress. In the film, the Turtles go on a hunt for a mysterious crime syndicate, but trouble arises when an army of mutants is unleashed upon them. The story explores themes of family, acceptance, and the desire to fit in.

Mutant Mayhem was produced by Nickelodeon Movies and Rogen, Goldberg, and James Weaver under their Point Grey Pictures banner. The film was announced in June 2020, with Rowe as director. Kyler Spears joined soon after as co-director. The animation was provided by Mikros Animation in Montreal and Paris and Cinesite in Vancouver and Montreal, and was primarily influenced by school notebook sketches. Seeking to explore the teenage aspect of the Turtles, the filmmakers drew inspiration from teenage coming-of-age films. The majority of the cast was announced in March 2023. Trent Reznor and Atticus Ross composed the score.

Mutant Mayhem was screened as a work-in-progress at the Annecy International Animation Film Festival on June 12, 2023, and was released by Paramount Pictures in the United States on August 2, 2023. It has grossed $167 million worldwide and received positive reviews for its performances, screenplay, and stylized animation; several critics considered it the best Turtles film. A follow-up television series, Tales of the Teenage Mutant Ninja Turtles, is set to premiere on Paramount+, and a sequel film is in development.