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Despicable Me 4 is an upcoming American animated comedy film produced by Illumination and distributed by Universal Pictures. It will serve as the sequel to Despicable Me 3 (2017), the fourth main installment, and the sixth installment overall in the Despicable Me franchise. The film is directed by Chris Renaud, co-directed by Patrick Delage (in his feature directorial debut), produced by Chris Meledandri and Brett Hoffman, and written by Mike White and Ken Daurio. It stars the voices of Steve Carell, Kristen Wiig, Will Ferrell, Miranda Cosgrove, Dana Gaier, Madison Polan, Sofia Vergara, Joey King, Stephen Colbert, Chloe Fineman, Pierre Coffin, and Steve Coogan.

Development on a fourth Despicable Me film began in September 2017. It was officially confirmed in February 2022, with Renaud, Delage, and White attached as director, co-director, and writer, respectively. Production was underway by June 2022. Most of the main voice cast was announced in January 2024, with Hoffman and Daurio revealed as co-producer and co-writer, respectively.

Despicable Me 4 is scheduled to be theatrically released in the United States on July 3, 2024.