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Teenage Mutant Ninja Turtles: Mutant Mayhem is a 2023 American animated superhero film based on the Teenage Mutant Ninja Turtles characters created by Peter Laird and Kevin Eastman. A reboot of the Turtles film series, it was directed by Jeff Rowe and Kyler Spears, and written by Seth Rogen, Evan Goldberg, and Rowe. It stars the voices of Micah Abbey, Shamon Brown Jr., Nicolas Cantu, and Brady Noon as the Turtles, alongside Ayo Edebiri, Maya Rudolph, John Cena, Rogen, Rose Byrne, Natasia Demetriou, Giancarlo Esposito, Jackie Chan, Ice Cube, and Paul Rudd. The story follows the Turtles as they seek acceptance and pursue a mysterious crime boss, Superfly, and his gang of mutants.

Plans for an animated Turtles film with Rogen began in 2018. The film was announced in June 2020, with Rogen, Goldberg, and James Weaver producing through their company Point Grey Pictures, and Rowe as director. Seeking to explore the teenage aspect of the Turtles, the filmmakers drew inspiration from teenage coming-of-age films. The animation was provided by Mikros Animation and Cinesite, and was influenced by school notebook sketches. In addition to a score composed by Trent Reznor and Atticus Ross, the film features various classic East Coast hip-hop songs.

Following a work-in-progress screening at the Annecy International Animation Film Festival on June 12, 2023, Mutant Mayhem was released by Paramount Pictures in the United States on August 2. It grossed $180.5 million worldwide and received positive reviews for its performances, screenplay, and stylized animation; several critics considered it the best Turtles film. Its nominations include Best Animated Feature at the 29th Critics' Choice Awards, 51st Annie Awards and 35th Producers Guild of America Awards.

A sequel is set for September 17, 2027, while a follow-up television series, Tales of the Teenage Mutant Ninja Turtles, debuted on the streaming service Paramount+ in August 2024.